Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning
نویسندگان
چکیده
منابع مشابه
Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning
BACKGROUND Human microbiota-associated (HMA) animal models relying on germ-free recipient mice are being used to study the relationship between intestinal microbiota and human disease. However, transfer of microbiota into germ-free animals also triggers global developmental changes in the recipient intestine, which can mask disease-specific attributes of the donor material. Therefore, a simple ...
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OBJECTIVE Fecal microbiota transplantation (FMT) is an investigational treatment for diseases thought to involve alterations in the intestinal microbiota including ulcerative colitis (UC). Case reports have described therapeutic benefit of FMT in patients with UC, possibly due to changes in the microbiota. We measured the degree to which the transplanted microbiota engraft following FMT in pati...
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15 صفحه اولHuman cell engraftment after busulfan or irradiation conditioning of NOD/SCID mice.
Human hematopoietic stem cell (HSC) xenotransplantation in NOD/SCID mice requires recipient conditioning, classically achieved by sublethal irradiation. Pretreatment with immunosuppressive and alkylating agents has been reported, but has not been rigorously tested against standard irradiation protocols. Here, we report that treatment of mice with a single dose (35 mg/kg) of Busilvex, an injecta...
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ژورنال
عنوان ژورنال: Microbiome
سال: 2017
ISSN: 2049-2618
DOI: 10.1186/s40168-017-0306-2